History of the Department

December 07,2015

PC-TraFFpublished!

The basic idea: we consider the genome as a document, genes as sentences, individual sequence elements as words, and apply mathematical concepts proven in linguistics.

PC-TraFF stands for "Potentially Collaborating Transcription Factor Finder". It is an information-theoretic method to identify, in a given set of genes, pairs of transcription factor binding sites. The corresponding transcription factors can be reasonably hypothesized to functionally interact in the regulation of these genes. When applied to breast cancer-associated genes, PC-TraFF found interacting TF pairs, some of them already known, others giving rise to interesting hypotheses for further validation.

July 02, 2015

A further refined version of Anirban Bhar's triclustering approach, EMOA-delta-TRIMAX, has been published. We acknowledge support by Erasmus Mundus and the ExITox project, funded by BMBF.

May 21, 2015

Anirban Bhar's triclustering approach provided the basis for illustrating the toxic  effect of naphthalene on lung and liver tissue. The work was part of our contribution to the ExITox project.

March 24, 2015

Our team member Anirban Bhar successfully passed his PhD defense. See here for his novel triclustering approach.

Congratulations, Anirban!

February 25, 2015

"Basic concepts of bioinformatics":
Lecture by E. Wingender at the Grodno State Medical University, Belarus

February 16, 2015

Project coordination meeting on Cardiovascular Bioinformatics with Dr. Shizuka Uchida and his team from Goethe University Frankfurt a.M.

January 28, 2015

New classification of human and rodent transcription factors published!

November 21, 2014

"Promises and pitfalls of ChIPseq data: the Fos case":
Lecture of E. Wingender at the Systems Biology Workshop of the EU project SYSCOL.

October 28, 2014

"Cell-specific features of enhancers, promoters, and gene regulatory networks":
Lecture of E. Wingender at RIKEN, Yokohama.