Cheminformatics and Imaging

Group of

Applied Bio(chem)informatics and Image Analysis


head


members

 

mission

 

Our work group aims at providing IT based solutions for biochemical aspects of the systems biology and systems medicine projects.

We develop and adapt software solutions to provide the required tools for medical research.
We accomplish this by applying and extending bioinformatics, cheminformatics and image processing methods to complement systems biology research questions integrating the means for statistical analysis. While extending our methodology toolbox we explicitly try to strengthen the planed analysis by integrating early on the requirements for the the statistical analysis of the output of our pipelines.
As more and more image based research is conducted and the number of created images per project increases, we develop the solutions for an automated analysis, e.g. AutoBuSTeD project, but if necessary can even venture out to help improve the acquisition setup.

 

research focus


For the past years we focus our research in the field of cystic fibrosis, where we still see an unmet demand for IT solutions to help this field.

Our CandActCFTR project aims at providing means to distil and curate compound libraries from literature and other online sources and combine this structured information for analysis.


CF is a good target for a system medicine approach

At a first glance, CF is a monocausal disease in which over 2000 putative mutations leading to various forms of phenotypes have been identified. Among these, about 300 variants define the more common types. The CFTR protein is only effective as an integral membrane protein, and as such, it is affected by transcription, translation, folding and degradation, as well as protein traficking processes. Thus, this monogenic disease has multiple sites for potential drug intervention during its life cycle and covers also protein structure variants. This makes it an interesting target for a system medicine approach. The life cycle of the protein offers also multiple modes to obtain information to annotate the system and the existing literature offers various annotations for specific combinations of mutations and read-outs (e.g. protein expression, functional patch clamp measurements, up to structure models and molecular dynamic simulations).

research projects

 

open thesis positions

We are currently seeking candidates to join our group at any of the following levels (Bachelor thesis, Master thesis)