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The research focus of our institute is on regulatory networks of cells and organisms. By applying a range of bioinformatics methods, we hope to contribute to unravel the underlying principles and, at the same time, to develop a couple of tools which may prove useful to the systems biology community. Like our research, our teaching in bioinformatics is very much biology-driven. In this sense, we try to convey the importance and the principles of bioinformatics to students in medicine, biology and computer sciences.

News

February 25, 2015

"Basic concepts of bioinformatics":
Lecture by E. Wingender at the Grodno State Medical University, Belarus

February 16, 2015

Project coordination meeting on Cardiovascular Bioinformatics with Dr. Shizuka Uchida and his team from Goethe University Frankfurt a.M.

January 28, 2015

New classification of human and rodent transcription factors published!

November 21, 2014

"Promises and pitfalls of ChIPseq data: the Fos case":
Lecture of E. Wingender at the Systems Biology Workshop of the EU project SYSCOL.

October 28, 2014

"Cell-specific features of enhancers, promoters, and gene regulatory networks":
Lecture of E. Wingender at RIKEN, Yokohama.

 

Featured paper

One of our most frequently cited papers is
“MATCH: a tool for searching transcription factor binding sites in DNA sequences”
by Kel et al., Nucleic Acids Res. 31:3576-3579, 2003 (>580 citations in Web of Science, >830 citations in Google Scholar).
It describes an algorithm to apply positional weight matrices, a common way to represent DNA-binding profiles of transcription factors (TFs), to the analysis of DNA sequences for potential TF binding sites. By default, it uses the largest library of such matrices available, the TRANSFAC database. MATCH is an advanced approach of the early MatInspector, which we co-developed with colleagues in Munich in 1995: Quandt et al., Nucleic Acids Res. 23:4878?4884, 1995 (>2240 citations in Web of Science, >2700 citations in Google Scholar). The tool is still state of the art, used by many reserachers and ourselves (69 citations since 2014).

February 19, 2015

 

Director

Prof. Dr. Edgar Wingender

Institute of Bioinformatics

Phone : +49 - (0)551 - 39 14912

Goldschmidtstr. 1

 

37077 Göttingen